i just used it on my whale in designs by cuties and it works great. I love it for baby things. Its nice and soft for them.
I have used all sorts of fleece and fur fabrics for my applique especially my bears and it works fine slow machine a little and put water soluble over the top cheers and happy stittching Shazells Teddy Towel and Baby Burper in projects
I do very few applique designs, but I would assume (dangerous) that it would be like using cotton. The fleece would be thicker, so would be a bit puffier. Hopefully, someone else who has used fleece with applique will come along. So don't give up waiting for an answer. And welcome to Cute
That's one good thing about the Cuties, somone is always peering thru files...*smiles* thanks :-)